Distribution of cefdinir, a third generation cephalosporin antibiotic, in serum and pulmonary compartments
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چکیده
منابع مشابه
Distribution of cefdinir, a third generation cephalosporin antibiotic, in serum and pulmonary compartments.
The distribution of a new cephalosporin, cefdinir, in serum, epithelial lining fluid (ELF), bronchial mucosa and alveolar macrophages was studied in 17 adults following a single oral dose of 300 or 600 mg of cefdinir; tissue samples being obtained by diagnostic bronchoscopy approximately 4 h after this dose. Mucosal biopsies were taken, alveolar macrophages harvested by lavage, and ELF volume d...
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Vibrio cholerae resistance to third-generation cephalosporins is rarely reported. We detected a strain that was negative for extended-spectrum β-lactamase and positive for the AmpC disk test, modified Hodge test, and EDTA disk synergy test and harbored the blaDHA-1 and blaNDM-1 genes. The antimicrobial drug susceptibility profile of V. cholerae should be monitored.
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To the Editor: Globally, antimicrobial drug resistance is rapidly rising, with resultant increased illness and death. Of particular concern is Escherichia coli, the most common bacterium to cause invasive disease in humans (1). In Europe, increasing proportions of bloodstream infections caused by E. coli are resistant to thirdgeneration cephalosporins (1,2). Resistant E. coli can be transmitted...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1996
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/37.2.331